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Data from Steam — Steam Web API Terms of Use. Last updated .
| Achievement | How to unlock | Unlocked by | Rarity |
|---|---|---|---|
| True Rogue Occultist | Playing Rasimov, activate the Immortal ability 6 times and finish the game with full health. | 1.4% | Very rare |
| Only a Man | Finish the game without purchasing a single skill upgrade. | 1.5% | Very rare |
| Dance with the Devil | Finish the game without opening a single locked chest or locked card. | 1.5% | Very rare |
| Road to Victory IV | Complete 120 missions. | 1.6% | Very rare |
| Isaac Would Be Proud | Finish the game without using any glyph. | 1.6% | Very rare |
| View every fate in the game. | 1.6% | Very rare | |
| Playing Aeon, finish the game by using Shadow Bolt to deal the killing blow on each of the guardians. | 1.7% | Very rare | |
| Unlock all of Rasimov's permanent upgrades. | 1.9% | Very rare | |
| Unlock all of Mukai's permanent upgrades. | 2% | Very rare | |
| Unlock all of Big Mo's permanent upgrades. | 2% | Very rare | |
| Playing Big Mo, finish the game without overheating once. | 2.1% | Very rare | |
| In a single playthrough, reroll 3 shops, bypass 2 cards, and cast destiny runes once. | 2.1% | Very rare | |
| In level 4, be within the range of a doll head's swirl of minions for 20 seconds. | 2.1% | Very rare | |
| Finish the game in Hard mode with Big Mo. | 2.2% | Very rare | |
| Have 15 health. | 2.4% | Very rare | |
| Finish the game in Hard mode with Mukai. | 2.5% | Very rare | |
| Unlock all of Aeon's permanent upgrades. | 2.5% | Very rare | |
| Finish the game in Hard mode with Rasimov. | 2.5% | Very rare | |
| Playing Mukai, finish the game by entering every card of every level (not counting extra cards or the shortcut card) | 2.6% | Very rare | |
| In a single playthrough, purchase 20 items in shops. | 2.8% | Very rare | |
| Finish the game in Hard mode with Aeon. | 3% | Very rare | |
| Survive a One-Shot Kill card in which you lost health. | 3.1% | Very rare | |
| Clear a level with special kills only. | 3.1% | Very rare | |
| Equip each of the 23 glyphs. | 3.6% | Very rare | |
| Survive the secret Cthulhu card in Hard mode | 3.8% | Very rare | |
| Complete 72 missions. | 4.4% | Very rare | |
| In a single playthrough, upgrade 6 skills from each of the three skill trees, and equip a gold glyph. | 6.3% | Rare | |
| Finish the game in Normal mode with Rasimov. | 6.4% | Rare | |
| Finish the game with at least 7 keys, 7 energy cells and 1,500 mana. | 6.9% | Rare | |
| Kill 13 creatures with a single blow. | 7.3% | Rare | |
| Accept 30 combat modifiers. | 7.4% | Rare | |
| Finish the game in Normal mode with Big Mo. | 8.7% | Rare | |
| Kill 7,500 creatures. | 9% | Rare | |
| Finish the game in Normal mode with Mukai. | 9% | Rare | |
| In a single playthrough, take no damage in a 3-skull combat card. Do this 10 times. | 9.5% | Rare | |
| Finish the game in Normal mode with Aeon. | 10.7% | Rare | |
| Play with an alternate outfit. | 14.4% | Rare | |
| Upgrade the same glyph twice in a single playthrough. | 14.8% | Rare | |
| Clear every challenge type once. | 18% | Rare | |
| Defeat 1,000 creatures with special kills. | 21.5% | Uncommon | |
| In a single combat, generate 60 reflected projectiles by shooting at a reflective-aura protected creature. | 21.9% | Uncommon | |
| Equip a gold glyph. | 22.5% | Uncommon | |
| Complete level 5. | 23.1% | Uncommon | |
| Complete 20 missions. | 24.5% | Uncommon | |
| Complete level 4. | 29.2% | Uncommon | |
| Complete level 3. | 37.2% | Uncommon | |
| Use a Continue. | 43.4% | Uncommon | |
| Complete 5 missions. | 44.8% | Uncommon | |
| Complete level 2. | 52.7% | Common | |
| Complete level 1. | 69.5% | Common |